Palladium-Catalyzed Strain-Enabled [2π + 2σ] Cycloadditions of Vinyl Bicyclo[1.1.0]butanes with Methyleneindolinones
A palladium-catalyzed [2π + 2σ] cycloaddition of vinyl bicyclo[1.1.0]butanes with methyleneindolinones has been developed. The reaction enables the construction of spirobicyclo[2.1.1]hexanes bearing an all-carbon quaternary center in moderate to good yields with excellent diastereoselectivities. This method features a broad substrate scope with good functional group compatibility. The practical utility of this protocol was further demonstrated by gram-scale synthesis and postsynthetic transformations of desired product.
Authors
- Jun‐An Xiao (ORCID: https://orcid.org/0000-0003-2921-8700)
- Wenjie Liang (ORCID: https://orcid.org/0000-0003-2947-2901)
- Chenxiang Lin (ORCID: https://orcid.org/0000-0001-7041-1946)
- Yumin Yang (ORCID: https://orcid.org/0000-0002-7390-5842)
- Yang Liu (ORCID: https://orcid.org/0000-0002-1789-6937)
- Wei‐Fang Su (ORCID: https://orcid.org/0000-0002-3375-4664)
- Hongyan Jiang (ORCID: https://orcid.org/0000-0003-3559-2774)
- Zhiping Liu (ORCID: https://orcid.org/0000-0003-1928-2178)
- Lan Zheng
- Wei Wang (ORCID: https://orcid.org/0000-0002-8614-7526)
Institutions
- Nanning Normal University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1021/acs.orglett.4c04224
- Citations
- 12
- Primary Topic
- Oxidative Organic Chemistry Reactions
- Type
- article
- Field-Weighted Citation Impact
- 3.00
Funders
- National Natural Science Foundation of China