Visible-Light Induced and Iron Peroxo-Promoted Radical Difunctionalization of Alkene for the Synthesis of β-Ketosulfone and α-Chloroketone
In this work, a switchable synthesis of β-ketosulfone and α-chloroketone through a radical difunctionalization of alkenes is reported. The transformation works well under iron peroxo species/photoredox dual catalysis and an open-flask atmosphere, and the reaction is highlighted with good yields and a broad reaction scope. Mechanism studies show that the reaction is initiated by a formal [4 + 2] cyclization of the sulfonyl radical in a regioselective manner.
Authors
- Guanyinsheng Qiu (ORCID: https://orcid.org/0000-0002-6587-8522)
- N. F. Chen
- Xingxian Zhang (ORCID: https://orcid.org/0000-0003-4474-7600)
- Yiliang Liao (ORCID: https://orcid.org/0000-0001-7122-3920)
- Meng Guan
- Chen Bao (ORCID: https://orcid.org/0000-0002-0915-0190)
- Xinyu Zhu (ORCID: https://orcid.org/0009-0003-5767-1120)
Institutions
- Jiaxing University (CN)
- Jiaxing Vocational Technical College (CN)
- Pharmaceutical Biotechnology (Czechia) (CZ)
- Zhejiang University of Technology (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1021/acs.joc.4c02720
- Citations
- 2
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- National Natural Science Foundation of China