Effect of β-catenin on hypoxia induced epithelial mesenchymal transition in HK-2 cells by regulating Brachyury
Herein, we demonstrated that β-catenin is overexpressed in hypoxia-induced HK-2 cells and promotes EMT and cell injury via activating Brachyury. These findings suggest that targeting β-catenin/Brachyury may be an effective new approach for treating RF.
Authors
- Haihui Yang (ORCID: https://orcid.org/0009-0000-0921-6180)
- Binying Min
- Mo Chen (ORCID: https://orcid.org/0000-0002-4409-6847)
- Wenjuan Sun
- Ping Sun
- Yongfu Li (ORCID: https://orcid.org/0000-0002-8667-0632)
- Jun Wang (ORCID: https://orcid.org/0009-0005-4854-7640)
- Diping Yu (ORCID: https://orcid.org/0009-0006-2412-2514)
Institutions
- Kunming University of Science and Technology (CN)
- Puer University (CN)
Publication Details
- Journal
- Biochemistry and Biophysics Reports
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1016/j.bbrep.2024.101907
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kunming Medical University