Efecto de la osteocalcina y el ejercicio físico, sobre la función cognitiva en adultos y adultos mayores: una revisión sistemática

It has been observed that practicing certain types of physical exercise stimulates Osteocalcin (OC) and its variants (ucOCN). Due to its ability to cross the blood-brain barrier, it can establish a link with the functioning of the right temporal cortex and stimulate learning and memory. This work involves a systematic review of the literature on the effect of OC on cognitive functions that are involved in adults and older adults practicing various types of physical exercise. The review was conducted under the PRISMA guideline in databases such as PubMed, Scielo, Google Scholar, Cochrane library, and Redalyc from 2019 to 2023. Out of the 35 articles reviewed, those without an experimental section, based on murine models and children, were eliminated according to the exclusion criteria. Finally, 16 articles were obtained. The conclusion reaffirms a connection between OC, physical exercise, and the association between motor and cognitive functions, such as attention, memory, and executive functions.