Contemporary insights into the collagen-stimulating mechanism of polylactic acid: a new paradigm in dermal fillers using poly-L-lactic acid fillers

Regardless of variances in lifestyle and environment, the initial indications of facial aging typically manifest between the ages of 20 and 30 years. Collagen loss is the most significant factor in the emergence of external signs of skin aging. Polylactic acid (PLA) is a notable stimulant of neocollagenesis and has become widely used as an injectable agent for augmenting facial soft tissues, particularly in the treatment of lipoatrophy, owing to its noteworthy therapeutic effectiveness. In particular, poly L-lactic acid demonstrates superior collagen-stimulating effects. This review explores the clinical applications and potential future developments of Gana Fill fillers, elucidating their advantages for achieving natural and harmonious outcomes. The emergence of Gana Fill fillers represents a new paradigm shift toward more advanced and effective techniques in aesthetic medicine, enabling practitioners to deliver superior outcomes and meet the evolving needs of patients.