Dietary Intervention with <em>Lycium barbarum</em> Polysaccharide and Quinoa Ultrafine Powder Ameliorates Lipid Metabolism in Nonalcoholic Fatty Liver Disease by Regulating Gut Microbiota and Activating AMPK/SREBP-1C/SCD-1 Signaling

Changes in intestinal microecology play a crucial role in the pathogenesis and progression of metabolic diseases. <em>Lycium barbarum</em> polysaccharide (LBP) and quinoa ultrafine powder diet is a promising sources of prebiotics. However, the potential synergistic effects of combining them as a microbiota-targeted dietary supplement to mitigate lipid accumulation in nonalcoholic fatty liver disease (NAFLD) remain unclear. Our study aims to provide evidence for the application food/nutrient synergy interventions in NAFLD management, and also to support the clarification of these mechanisms. Following 12 weeks of a high-fat diet (HFD)-inducing NAFLD and an 11-week intervention in rats, the combination of LBP and quinoa ultrafine powder significantly decreased hepatocyte lipid accumulation and improved lipid metabolism disorders compared with those using either LBP or quinoa ultrafine powder alone. The combination increased beneficial intestinal microbiota, such as <em>Lactobacillus acidophilus</em>, <em>Roseburia</em>, <em>Ruminococcus2</em>, and <em>Prevotella</em>, promoting the production of short-chain fatty acids, notably butyric acid, and then activated AMPK/SREBP-1C/SCD-1 signaling. Combining LBP with quinoa ultrafine powder is a promising microbiota-targeted dietary supplement for ameliorating lipid disorders in NAFLD.