Oral Lactoferrin‐Responsive Formulation Anchoring around Inflammatory Bowel Region for IBD Therapy
Oral formulation is the ideal treatment method for inflammatory bowel disease (IBD) therapy, but the mucosal damage and diarrhea symptoms impede the drug retention around the inflammatory region, severely limiting IBD therapeutic efficacy. To address this, an oral astaxanthin (Ast) precise delivery formulation is developed with the selective Ast anchoring around the inflammatory region by the novel lactoferrin (LF)-responsive flocculation. This formulation also heightens the apparent solubility of Ast with the minimized edible safety risks for the edible raw materials. For in vivo IBD therapy, the precise delivery formulation exhibits remarkable outcomes, including a significant increase in colon length and a 100% survival rate. Furthermore, it is verified that the mechanism of treatment is primarily attributed to the improved immunoregulation, epithelial repair, and gut microbiota remodeling after the LF-responsive flocculation. This effective inflammatory-responsive delivery design is instructive and valuable to develop more precise delivery systems for IBD therapy.
Authors
- Zheng Zhu (ORCID: https://orcid.org/0000-0002-4112-5294)
- Xueru Sheng (ORCID: https://orcid.org/0000-0003-3517-1320)
- Jinfan Yang (ORCID: https://orcid.org/0000-0003-1104-1329)
- Mingqian Tan (ORCID: https://orcid.org/0000-0002-7535-0035)
- Yucheng Zhou (ORCID: https://orcid.org/0000-0003-3856-0807)
- Hao Wu (ORCID: https://orcid.org/0000-0003-1262-5932)
- Xin Zhou (ORCID: https://orcid.org/0000-0003-2814-3399)
- Zhengqing Li (ORCID: https://orcid.org/0000-0001-8633-6055)
- Wen Luo (ORCID: https://orcid.org/0000-0003-4669-9120)
- Peng Xu (ORCID: https://orcid.org/0000-0002-8284-5730)
- Ji Xu
- Ning Shang (ORCID: https://orcid.org/0000-0003-0934-4443)
- Xiaobin Ma
- Mingzhen Zhang (ORCID: https://orcid.org/0000-0002-4686-6526)
- Hui Zhou (ORCID: https://orcid.org/0000-0002-7466-5350)
Institutions
- Zhejiang Provincial People's Hospital (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xijing Hospital (CN)
- Hangzhou Medical College (CN)
- Shaanxi University of Science and Technology (CN)
- Xi'an Jiaotong University (CN)
- Dalian Polytechnic University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Advanced Healthcare Materials
- Published
- 2024-12-25
- DOI
- https://doi.org/10.1002/adhm.202402731
- Citations
- 6
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 1.86
Funders
- National Natural Science Foundation of China
- Ministry of Education of the People's Republic of China
- Education Department of Shaanxi Province
- Natural Science Foundation of Shaanxi Provincial Department of Education
- Chunhui Project Foundation of the Education Department of China