Effect of nanocluster polyoxometalate {mo72fe30} on morphofunctional state of macrophages in cultures

The aim of this work was to study the effect of nanocluster polyoxometalate {Mo72Fe30} on the macrophage link of the immune system. In vitro studies of polyoxometalate on macrophage cultures allowed us to evaluate the reaction of immune system cells (in particular, peritonial and alveolar macrophages) to nanoparticles. The analysis of the obtained data allowed to establish that {Mo72Fe30} is not toxic for peritonial and alveolar macrophages, has no significant effect on the morphology of cells, as well as on the activity of α-naphthylacetate esterase. However, it significantly reduces phagocytic activity when cells are cultured with POM, which may indicate possible polarisation of macrophages. The obtained results confirm the possibility of using {Mo72Fe30} in the field of biomedicine.