Synthesis, characterization and measurement of antimicrobial activity of (6Z,15Z)-4,18-dioxa-9,13-dithia-7,15-diaza-1,2(1,4),5,8,11,14,17(1,2)- heptabenzenecyclononadecaphan-6,15-diliene and its palladium(II) chloride complex

To synthesize the Schiff base with the desired properties, a transition from a monomeric molecule to a macrocyclic structure was made. For this purpose; (oxy)-dibenzaldehyde dibenzaldehyde derivative, (oxy)bis(N-prop)-1-en-2-yl-aniline derivative, (oxy)-dianiline derivative and (sulfanediyl)-dianiline compounds were obtained at the end of four different reaction processes. In the last step of these reactions, a macrocyclic compound (6Z,15Z)-4,18-dioxa-9,13-dithia-7,15-diaza-1,2(1,4),5,8,11,14,17(1,2)-heptabenzenecyclononadecaphan- 6,15-diene Schiff base was obtained by condensation method. As a result of the reaction of this product with PdCl2, (6Z,15Z)-4,18-dioxa-9,13-dithia-7,15-diaza-1,2(1,4),5,8,11,14,17(1,2)-heptabenzenecyclononadecaphan-6,15-dylene palladium(II) chloride product was obtained and a new biologically active metal complex was synthesized. Their structures were identified by characterizing them according to elemental analysis (CHN), thermal analysis, PXRD, conductivity measurements, FT-IR, and UV-vis spectra. Spectral data confirmed the structure of azomethine (-C=N-) and phenolic OH groups with a nitrogen atom of the metal-coordinated ligand and the presence of metal ions. As a result of this information, a tetrahedral geometry was suggested for the Pd(II) complex. Antimicrobial activities of the synthesized metal complex were tested. Pd(II) complex showed the highest cytotoxicity (MIC value 11.25±0.14 µg/mL) effect, comparable to other cis-platinum-based drugs.