Synthesis, Docking and Cytotoxicity Evaluation of 3- heterocycles as Potential Anti-Cancer Agents

5´-cyanomeridianine G analogues produce from 3-cyanoacetyl indole accomplished in to steps by treatment with a mixture ofpiperidine andtriethylorthoformate in DMF and then cyclization of the resulting enaminonitrile with guanidine and thiourea are described. The biological evaluation against a range of cancer cells lines showed that indolylpyrimidinethione6was more cytotoxic against Lung carcinoma cell line (A549) with inhaibition activity of 95.4 % and it has the highst antioxidant activities. While the cyanomeridianine G 5 showed high cytotoxic activity against MCF7, A549 and HCT116 with 100, 88.6 and 74.6 % inhibition in cell viability, respectively.