Activated DRP1 promotes mitochondrial fission and induces glycolysis in ATII cells under hyperoxia
Hyperoxia exposure leads to increased mitochondrial fission in ATII cells and mediates the reprogramming of glucose metabolism via the DRP1 signaling pathway. Inhibiting the activation of DRP1 signaling pathway may be a promising therapeutic target for BPD.
Authors
- Dingning Zhang (ORCID: https://orcid.org/0000-0003-4616-1232)
- Danni Li (ORCID: https://orcid.org/0000-0002-1882-7394)
- Jianhua Fu
- Haiyang Yu
- T. Sun
Institutions
- China Medical University (CN)
Publication Details
- Journal
- Respiratory Research
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1186/s12931-024-03083-8
- Citations
- 6
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Natural Science Foundation of China