Tunable base-controlled chemoselective synthesis of trifluoromethyl-containing <i>N</i>-substituted benzimidazole-2-thiones and monofluorinated 4<i>H</i>-benzo[4,5]imidazo[2,1-<i>b</i>][1,3]thiazine
A highly efficient base-controlled synthesis of <i>N</i>-β-trifluoromethyl-substituted 2<i>H</i>-benzo[<i>d</i>]imidazole-2-thiones and 2-fluoro-4<i>H</i>-benzo[4,5]imidazo[2,1-<i>b</i>][1,3]thiazines <i>via</i> hydroamination or defluorinative cyclizations of α-(trifluoromethyl)styrenes with 2-mercaptobenzimidazole was developed.
Authors
- Qingchun Huang (ORCID: https://orcid.org/0000-0003-1731-8384)
- Song Cao (ORCID: https://orcid.org/0000-0002-3231-6136)
- Zhudi Sun
- Jia‐Qi Huang (ORCID: https://orcid.org/0000-0001-7394-9186)
- Yupian Deng
- Yuhao Qian
- Ronghua Zhuge
Institutions
- East China University of Science and Technology (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1039/d4ob01999g
- Citations
- 3
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.75
Funders
- National Natural Science Foundation of China