NXT629 Ameliorates Cholesterol Gallstones in Mice Model by Improving Lipid Metabolism Disorder and Cholesterol Homeostasis Through Inhibiting the GPAM Pathway
NXT629 can inhibit CG formation, improve lipid metabolism disorders and cholesterol homeostasis by inhibiting GPAM expression, suggesting that NXT629 may serve as a potential therapeutic strategy for cholesterol stones prevention and treatment.
Authors
- Lai-bin Zou
- Keqiang Ma (ORCID: https://orcid.org/0000-0001-9617-0538)
- Xubin Qiu (ORCID: https://orcid.org/0000-0001-5590-2165)
- Hao Chen (ORCID: https://orcid.org/0000-0001-8090-8593)
- Shenglan Guo
- Lin Liang (ORCID: https://orcid.org/0000-0002-7753-7004)
Institutions
- New Huadu Business School (CN)
Publication Details
- Journal
- Digestive Diseases and Sciences
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1007/s10620-024-08798-8
- Citations
- 2
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.57