Intrinsic Muscle Stem Cell Dysfunction Contributes to Impaired Regeneration in the <i>mdx</i> Mouse
Our study provides evidence that dystrophin deficiency in MuSCs and myofibres together contributes to progression of DMD. Ongoing muscle damage stimulates MuSC activation; however, aberrant intrinsic MuSC polarity and stem cell commitment deficits due to the loss of dystrophin impair muscle regeneration. Our study provides in vivo validation that dystrophin-deficient MuSCs undergo fewer asymmetric cell divisions, instead favouring symmetric expansion.
Authors
- Morten Ritso (ORCID: https://orcid.org/0000-0003-4266-0149)
- Michael A. Rudnicki (ORCID: https://orcid.org/0000-0002-3866-5249)
- Marie‐Claude Sincennes (ORCID: https://orcid.org/0000-0002-1961-426X)
- Peter Feige (ORCID: https://orcid.org/0000-0002-6530-8351)
- Alexander Y. Lin (ORCID: https://orcid.org/0000-0002-8702-5539)
- Marie Catenacci
- Marie E. Esper (ORCID: https://orcid.org/0000-0001-8741-6938)
- Caroline Brun (ORCID: https://orcid.org/0000-0003-2824-5221)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Université du Québec à Chicoutimi (CA)
- Centre National de la Recherche Scientifique (FR)
- University of British Columbia (CA)
- University of Ottawa (CA)
- Inserm (FR)
- Ottawa Hospital (CA)
- Institut National de la Recherche Scientifique (CA)
- Institut NeuroMyoGène (FR)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1002/jcsm.13682
- Citations
- 11
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.57
Funders
- Stem Cell Network