NLRP3 Inflammasome Activation and Altered Mitophagy Are Key Pathways in Inclusion Body Myositis
There is activation of the NLRP3 inflammasome in IBM, along with altered mitophagy, particularly in males, which is of potential therapeutic significance. These findings suggest sex-specific mechanisms in IBM that warrant further investigation.
Authors
- Jay Mandrekar
- Eugenia Trushina (ORCID: https://orcid.org/0000-0002-6291-2860)
- Xu Hou (ORCID: https://orcid.org/0000-0003-3011-4378)
- William S. Harmsen (ORCID: https://orcid.org/0000-0001-7134-5362)
- Fabienne C. Fiesel (ORCID: https://orcid.org/0000-0002-1919-9676)
- Jens O. Watzlawik (ORCID: https://orcid.org/0000-0003-0610-0267)
- Huanyao Gao (ORCID: https://orcid.org/0000-0002-9441-9579)
- Wolfdieter Springer (ORCID: https://orcid.org/0000-0002-1178-3149)
- Elie Naddaf (ORCID: https://orcid.org/0000-0001-6212-1236)
- Ian R. Lanza (ORCID: https://orcid.org/0000-0002-9858-3384)
- Eileen Kokesh
- Thi Kim Oanh Nguyen (ORCID: https://orcid.org/0000-0002-6068-6222)
Institutions
- Mayo Clinic (US)
- Jacksonville College (US)
- WinnMed (US)
- Mayo Clinic in Florida (US)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1002/jcsm.13672
- Citations
- 11
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 4.25
Funders
- Michael J. Fox Foundation for Parkinson's Research
- Alzheimer's Association
- Florida Department of Health
- National Institutes of Health
- Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston
- National Institute of Neurological Disorders and Stroke
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Center for Advancing Translational Sciences