Hearing modulation affects Alzheimer’s disease progression linked to brain inflammation: a study in mouse models
HL significantly increases Aβ accumulation in the brain. Furthermore, HL activates astrocytes and microglia, leading to increased neuroinflammation and thereby accelerating AD progression. These findings strongly suggest that HL contributes autonomously to neuroinflammation, highlighting the potential for early intervention in HL to reduce AD risk.
Authors
- Byeong C. Kim (ORCID: https://orcid.org/0000-0001-6827-6730)
- Jihoon Jo (ORCID: https://orcid.org/0000-0003-1238-7882)
- Sungsu Lee (ORCID: https://orcid.org/0000-0002-0755-110X)
- Won-Seok Choi
- Han‐Seong Jeong (ORCID: https://orcid.org/0000-0001-6921-6625)
- Munyoung Choi
- Hyong‐Ho Cho (ORCID: https://orcid.org/0000-0002-1331-4039)
- Sujeong Jang (ORCID: https://orcid.org/0000-0001-8673-7887)
- Su-Jin Han (ORCID: https://orcid.org/0000-0002-0876-1352)
- Yoo‐Seung Ko
- Hyung Joon Park (ORCID: https://orcid.org/0000-0002-6740-6262)
- Young-Kyoung Ryu
Institutions
- Chonnam National University (KR)
- University of Washington (US)
- Chonnam National University Hospital (KR)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1186/s10020-024-01040-1
- Citations
- 3
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.74
Funders
- National Research Foundation
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Ministry of Education, Science and Technology