The Effects of Natural and Artifical Sweeteners on Glucose Intolerance, Liver Enzymes and Oxidative Stress in Rats with Type 2 Diabetes

The impacts of artificial and sweeteners on liver enzymes, glucose intolerance, and oxidative stress were investigated in the present research. Sixty adult male Wistar rats were indiscriminately distributed to two groups, involving 30 in each. The first group was made diabetic with streptozocin, and the second group was called the healthy control group. Then, these groups were divided into 3 different groups again and these groups were given 250 mg/kg daily of Aspartame and Stevia and followed for 5 weeks to compare their effects. A comparison between the groups indicated that the diabetic stevia group had lower levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood glucose, and HbA1c values than the diabetic aspartame group (p