Lactate Promotes Hypoxic Granulosa Cells’ Autophagy by Activating the HIF-1α/BNIP3/Beclin-1 Signaling Axis
These findings unveil a novel mechanism by which hypoxia regulates GC autophagy through lactate production, highlighting its potential role in sustaining follicular development under hypoxic conditions.
Authors
- Gang Wu (ORCID: https://orcid.org/0000-0002-1678-5864)
- Ming Shen (ORCID: https://orcid.org/0000-0003-1219-225X)
- Min Chen (ORCID: https://orcid.org/0000-0002-0140-4192)
- Hongmin Li (ORCID: https://orcid.org/0009-0003-2739-2374)
- Xiumei Lu
- Yitong Pan
- H. Liu (ORCID: https://orcid.org/0000-0002-7613-4983)
Institutions
- Nanjing Agricultural University (CN)
Publication Details
- Journal
- Genes
- Published
- 2024-12-26
- DOI
- https://doi.org/10.3390/genes16010014
- Citations
- 7
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 2.71
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities