AKT1-Mediated NOTCH1 phosphorylation promotes gastric cancer progression via targeted regulation of IRS-1 transcription
AKT1 induces the Notch1 phosphorylation and promotes the activation and nuclear translocation of Notch1-IC by targeting the regulation of IRS-1, thereby advancing the progression of GC.
Authors
- Ya Zheng (ORCID: https://orcid.org/0000-0002-9238-8326)
- Yongning Zhou (ORCID: https://orcid.org/0000-0002-7304-929X)
- Yuling Gan
- Min Liu (ORCID: https://orcid.org/0000-0001-6260-0480)
- Lingshan Zhou (ORCID: https://orcid.org/0000-0002-0095-3376)
- Yu‐Ping Wang (ORCID: https://orcid.org/0000-0001-9340-5864)
- Qian Qiao (ORCID: https://orcid.org/0009-0009-2471-4423)
- Yang Yuan (ORCID: https://orcid.org/0009-0005-6235-3498)
- Yingying Mi
Institutions
- Gansu Provincial Hospital (CN)
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
- University of South China (CN)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1007/s00432-024-06039-z
- Citations
- 4
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 1.14
Funders
- Lanzhou University
- National Natural Science Foundation of China
- Natural Science Foundation of Gansu Province