Unbalanced long-chain fatty acid beta-oxidation in newborns with cystic fibrosis and congenital hypothyroidism
Decreased total long-chain acylcarnitine concentrations in newborns with cystic fibrosis and congenital hypothyroidism suggest diminished beta-oxidation. However, the unexpected relative increase in C18:2 indicates selective preservation of linoleic acid beta-oxidation in both conditions. This is especially surprising in cystic fibrosis where linoleic acid levels become diminished and suggests that linoleic acid beta-oxidation contributes to the deficiency of linoleic acid in cystic fibrosis.
Authors
- Catherina T. Pinnaro (ORCID: https://orcid.org/0000-0001-6450-0918)
- Andrew W. Norris (ORCID: https://orcid.org/0000-0001-8396-9543)
- Kelli K. Ryckman (ORCID: https://orcid.org/0000-0002-9496-4147)
- Aliye Uç (ORCID: https://orcid.org/0000-0003-2004-5743)
Institutions
- University of Iowa (US)
- Fraternal Order of Eagles (US)
- Indiana University Bloomington (US)
Publication Details
- Journal
- Molecular Genetics and Metabolism Reports
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1016/j.ymgmr.2024.101182
- Citations
- 1
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.38
Funders
- U.S. Department of Health and Human Services
- Michigan Department of Health and Human Services