Maternal Smoking During Pregnancy Interacts With Genetic Factors to Increase Risk for Low Birth Weight but Not Harmful Offspring Smoking Behaviors in Europeans
We detected interactions between maternal smoking and genetic factors to influence birth weight; these interactions were detectable at both the single-nucleotide polymorphism and gene levels. Many of the genes detected to interact with maternal smoking to influence birth weight have other reported associations with height or smoking-related traits. For smoking initiation, we detected a negative interaction between maternal smoking and polygenic risk, as well as evidence of gene-environment correlation.
Authors
- Pamela N Romero Villela (ORCID: https://orcid.org/0000-0002-6401-3260)
- Marissa A. Ehringer (ORCID: https://orcid.org/0000-0003-0388-7375)
- Matthew C. Keller (ORCID: https://orcid.org/0000-0002-6075-9882)
- Jared V. Balbona (ORCID: https://orcid.org/0000-0003-4466-248X)
- Kristen M. Kelly (ORCID: https://orcid.org/0000-0003-3631-3730)
Institutions
- University of Colorado Boulder (US)
- Institute for Behavioral Medicine (US)
Publication Details
- Journal
- Nicotine & Tobacco Research
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1093/ntr/ntae310
- Primary Topic
- Smoking Behavior and Cessation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Colorado State University
- National Institutes of Health
- University of Colorado Boulder