Sensitive liquid biopsy monitoring correlates with outcome in the prospective international GPOH-DCOG high-risk neuroblastoma RT-qPCR validation study
This study validates the association of not clearing of BM metastases by sensitive RT-qPCR detection with very poor outcome. We therefore propose implementation of RT-qPCR for minimal residual disease testing in neuroblastoma to guide therapy.
Authors
- Lieke M. J. van Zogchel (ORCID: https://orcid.org/0000-0003-3557-7195)
- Marta Fiocco (ORCID: https://orcid.org/0000-0001-5588-0277)
- Janine Stutterheim (ORCID: https://orcid.org/0000-0002-9828-0834)
- Esther M. van Wezel
- Nina U. Gelineau (ORCID: https://orcid.org/0009-0000-0348-8724)
- Boris Decarolis (ORCID: https://orcid.org/0000-0002-1607-0543)
- C. Ellen van der Schoot (ORCID: https://orcid.org/0000-0002-8065-3540)
- Frank Berthold (ORCID: https://orcid.org/0000-0002-7613-1723)
- Godelieve A.M. Tytgat (ORCID: https://orcid.org/0000-0003-4452-0748)
- Barbara Hero (ORCID: https://orcid.org/0000-0003-4129-890X)
- Thorsten Simon (ORCID: https://orcid.org/0000-0002-3425-8451)
- Max Maria van Noesel (ORCID: https://orcid.org/0000-0001-7738-0353)
- Lily Zappeij‐Kannegieter (ORCID: https://orcid.org/0000-0002-5493-5149)
- Roswitha Schumacher‐Kuckelkorn
Institutions
- Leiden University (NL)
- University of Cologne (DE)
- Utrecht University (NL)
- Leiden University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Sanquin (NL)
- Princess Máxima Center (NL)
- Cancer Genomics Centre (NL)
- Amsterdam University Medical Centers (NL)
- University Hospital Cologne (DE)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1186/s13046-024-03261-y
- Citations
- 4
- Primary Topic
- Neuroblastoma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.48
Funders
- KWF Kankerbestrijding