Granulomatous inflammatory responses are elicited in the liver of PD-1 knockout mice by <i>de novo</i> genome mutagenesis
These results support our hypothesis about the physiological function of PD-1 and address the mechanistic reasons for immune-related adverse events observed in cancer patients having PD-1-blockade immunotherapies.
Authors
- Yuta Ishii (ORCID: https://orcid.org/0000-0003-3214-2014)
- Yoshihide Kakimoto
- Toshiaki Shigeoka (ORCID: https://orcid.org/0009-0001-5612-1229)
- Michito Hamada (ORCID: https://orcid.org/0000-0002-4737-1007)
- Ai Ozaki
- Yusuke Osaki (ORCID: https://orcid.org/0000-0001-6588-5442)
- Akihiko Ito (ORCID: https://orcid.org/0000-0002-6116-1700)
- Fuka Takeuchi (ORCID: https://orcid.org/0009-0007-9110-6490)
- Azusa Yoneshige (ORCID: https://orcid.org/0009-0007-4638-8476)
- Yasumasa Ishida (ORCID: https://orcid.org/0009-0007-1431-1941)
- Ilamangai Nagaretnam
- Masaru Tamura
- Kazushige Sato
- Takayuki Sakimura
Institutions
- University of Tsukuba (JP)
- Kindai University Hospital (JP)
- RIKEN BioResource Research Center (JP)
- Nara Institute of Science and Technology (JP)
- Kindai University (JP)
Publication Details
- Journal
- Discovery Immunology
- Published
- 2024-12-25
- DOI
- https://doi.org/10.1093/discim/kyae018
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.85
Funders
- Nara Institute of Science and Technology
- Ono Pharmaceutical
- Japan Society for the Promotion of Science