Staged Screening Identifies People with Biomarkers Related to Neuronal Alpha‐Synuclein Disease
Remote screening for hyposmia and reduced DAT-SPECT binding identifies participants with a high proportion positive aSynSAA. Longitudinal data will be essential to define progression patterns in these individuals to ultimately inform recruitment into disease modification clinical trials. ANN NEUROL 2025;97:730-740.
Authors
- Michael C. Brumm (ORCID: https://orcid.org/0000-0002-3173-9989)
- Ethan Brown (ORCID: https://orcid.org/0000-0001-9744-8562)
- Monica Korell
- Lana M. Chahine (ORCID: https://orcid.org/0000-0003-2521-7196)
- Luis Concha‐Marambio (ORCID: https://orcid.org/0000-0002-9454-8389)
- Ryan Kurth (ORCID: https://orcid.org/0009-0004-4569-5763)
- Chelsea Caspell‐Garcia (ORCID: https://orcid.org/0000-0002-0933-1039)
- Andrew D. Siderowf (ORCID: https://orcid.org/0000-0002-1750-7698)
- Caroline M. Tanner (ORCID: https://orcid.org/0000-0002-3775-5082)
- Sohini Chowdhury (ORCID: https://orcid.org/0009-0009-8321-0081)
- Claudio Soto (ORCID: https://orcid.org/0000-0002-3412-0524)
- Craig Stanley
- Laura Heathers (ORCID: https://orcid.org/0009-0008-1097-2678)
- Kenneth Marek (ORCID: https://orcid.org/0000-0002-4197-5627)
- Maggie Kuhl (ORCID: https://orcid.org/0009-0009-3187-4572)
- Caroline Gochanour (ORCID: https://orcid.org/0009-0009-3263-8344)
- Kimberly Fabrizio
- Christopher S. Coffey (ORCID: https://orcid.org/0000-0003-1193-2041)
- Tatiana M. Foroud
- Tanya Simuni
- Micah J. Marshall
- Bridget McMahon (ORCID: https://orcid.org/0009-0001-2118-9565)
Institutions
- Northwestern University (US)
- University of Iowa (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- Michael J. Fox Foundation (US)
- Institute for Neurodegenerative Disorders (US)
- Amprion (United States) (US)
- Indiana University – Purdue University Indianapolis (US)
- University of Pennsylvania (US)
- The University of Texas Health Science Center at Houston (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1002/ana.27158
- Citations
- 8
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.95
Funders
- Michael J. Fox Foundation for Parkinson's Research
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Sanofi
- Biogen
- Teva Pharmaceutical Industries
- Celgene
- Jazz Pharmaceuticals
- Neurocrine Biosciences
- Verily Life Sciences
- Voyager Therapeutics
- Servier
- H. Lundbeck A/S
- Sun Pharma
- Genentech
- Allergan
- Avid Radiopharmaceuticals