A New Parameter to Predict the Development of Aortic Sclerosis in Hypertensive Patients: The Aggregate Index of Systemic Inflammation

Objective:The aim of this study is to investigate the relationship between the presence of aortic valve sclerosis (AVS) and aggregate index of systemic inflammation (AISI), in patients with hypertension (HT). Material and Methods:Patients with HT diagnosis of 10 years or more who applied to the cardiology outpatient clinic between January and June 2024 were included in our study.Patients were divided into two groups as AVS detected (84 patients) and non-AVS detected (293 patients).AISI was calculated with the neutrophil x platelet x monocyte / lymphocyte formula.Results: AISI was found to be statistically higher in the AVS detected group [421 (127-3400) and 141.57(21-2332); p<0.001].Apart from AISI, age, diabetes history, left ventricular wall thickness and mitral valve early diastolic wave were found to be different between the two groups.In multivariate regression analysis, age (p<0.001),left ventricular posterior wall diameter (p=0.012) and AISI (p<0.002) were found to be independent predictors of AVS development. Conclusion:We found that AISI can be used to detect AVS in long-term HT patients.High AISI values in HT patients can be used as an early warning parameter for poor prognosis.