Current concepts of the etiology and pathogenesis of gastroduodenitis (review)

A review of domestic and foreign scientific publications from 2018 to 2023 was conducted. The search was carried out using the Pubmed biomedical research database and the Russian Science Citation Index. 1673 articles were found, using keywords. Various etiological and pathogenetic variants of gastroduodenitis (GD) are considered. One of the most common pathogens of gastroduodenal pathology is Helicobacter pylori ( Hp ), which, due to its virulence factors, can persist for a long time on the mucous membrane of the stomach and duodenum, thereby causing its inflammation, subsequently leading to gross damage to the mucosa and complications of gastrointestinal tract. Today, despite the prevalence of Hp , many new etiological agents are found: cytomegalovirus, Epstein - Barr viruses, Lamblia intestinalis, Blastocystis spp ., Entamoeba spp . and various factors contributing to the development of this disease. For example, such as human constitution, environment, gender differences, age, genetics, drug exposure, stress, the relationship of perinatal brain lesions, endothelial dysfunction and immunity with the detection of GD has also been described. Every year the range of etiological agents expands, which leads to changes in the pathogenesis of GD.