A novel ultrasound-driven piezoelectric GBR membrane dispersed with boron nitride nanotubes promotes bone regeneration and anti-bacterial properties
Bone graft absorption and infection are the major challenges to guided bone regeneration(GBR), yet the GBR membrane is neither osteogenic nor antibacterial. Hence, we followed sono-piezo therapy strategy by fabricating an electrospun membrane dispersed with boron nitride nanotubes. The PLLA/Gelatine/PDA@BNNT (PGBT) membrane has improved mechanical and biocompatible properties and generate piezovoltages of 130 mV when activated by ultrasound stimulation under 100 mW/cm<sup>2</sup> without extra polarization. The PGBT with ultrasound is conducive to cellular osteogenesis, barrier function, and shows antibacterial rate of about 40 %. The rat cranial defect experiments revealed that PGBT with ultrasound could promote osteogenesis in-vivo and show great potentials for vertical bone defect repair.
Authors
- Fei Yang (ORCID: https://orcid.org/0000-0001-9719-1314)
- Youcheng Yu (ORCID: https://orcid.org/0000-0001-9716-245X)
- Yang Sun (ORCID: https://orcid.org/0000-0002-4016-753X)
- Ruixue Li
- Keshi Zhu
- Shi Yin
- Yixiao Xing
- Yiling Yang
- Wanjing Xu
Institutions
- Sun Yat-sen University (CN)
- Fudan University (CN)
- Shanghai Xuhui Central Hospital (CN)
- Zhongshan Hospital of Xiamen University (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Materials Today Bio
- Published
- 2024-12-25
- DOI
- https://doi.org/10.1016/j.mtbio.2024.101418
- Citations
- 10
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 1.84
Funders
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality