Dietary Carrageenan Amplifies the Inflammatory Profile, but not Permeability, of Intestinal Epithelial Cells from Patients With Crohn’s Disease
Dietary CGN caused upregulation of inflammatory markers and affected cytokine release of intestinal epithelial cells from CD patients, while permeability remained unaltered. When inflammation was already present, this pro-inflammatory effect was more pronounced, suggesting a role for dietary CGN during active CD.
Authors
- Christophe Matthys (ORCID: https://orcid.org/0000-0003-1770-6862)
- Severine A.R.A. Vermeire (ORCID: https://orcid.org/0000-0001-9942-3019)
- Marc Ferrante (ORCID: https://orcid.org/0000-0003-1492-0716)
- Kaline Arnauts (ORCID: https://orcid.org/0000-0003-0872-7776)
- Eva Vissers (ORCID: https://orcid.org/0000-0001-7709-3223)
- Lorenzo Giorio (ORCID: https://orcid.org/0000-0001-8490-0150)
- Bram Verstockt (ORCID: https://orcid.org/0000-0003-3898-7093)
- Ward Zadora (ORCID: https://orcid.org/0000-0002-9958-3474)
- João Sabino (ORCID: https://orcid.org/0000-0002-8892-7075)
- Judith Wellens (ORCID: https://orcid.org/0000-0002-1647-8151)
Institutions
- Universitair Ziekenhuis Leuven (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Inflammatory Bowel Diseases
- Published
- 2024-12-24
- DOI
- https://doi.org/10.1093/ibd/izae306
- Citations
- 8
- Primary Topic
- Digestive system and related health
- Type
- article
- Field-Weighted Citation Impact
- 4.40
Funders
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- Vlaamse regering