Neutralization of an Oxytocin Derivative by 355 nm Photocleavage in High Vacuum
Abstract Controlling the charge state of biomolecules in high vacuum enables experiments in molecular physics and physical chemistry, particularly in applications of mass spectrometry, trapping and cooling, spectroscopy and matter‐wave interferometry. Here we investigate the synthesis, verification and gas phase photolysis of nitrodibenzofuranmethyl aryl ether derivatives. These photocages are chosen because their absorption maximum can be tuned to near 355 nm, where intense pulsed laser light is available. We demonstrate efficient gas‐phase cleavage of a photoactive nitrodibenzofuranmethyl aryl ether derivative, both free and attached to oxytocin. This enables the neutralization of a polypeptide derivative in high vacuum using a wavelength outside the absorption spectrum of natural amino acids.
Authors
- Tim Kostersitz (ORCID: https://orcid.org/0009-0001-4316-1803)
- Yong Hua (ORCID: https://orcid.org/0000-0003-4799-2871)
- Marcel Mayor (ORCID: https://orcid.org/0000-0002-8094-7813)
- Valentin Köhler (ORCID: https://orcid.org/0000-0002-7828-423X)
- Markus Arndt (ORCID: https://orcid.org/0000-0002-9487-4985)
- Daniel Häußinger (ORCID: https://orcid.org/0000-0002-4798-0072)
- Martin F. X. Mauser (ORCID: https://orcid.org/0000-0001-5391-2837)
- Philipp Geyer (ORCID: https://orcid.org/0000-0003-0128-9849)
- Marcel Strauß (ORCID: https://orcid.org/0009-0009-5742-3278)
Institutions
- University of Vienna (AT)
- University of Basel (CH)
- Vienna Center for Quantum Science and Technology (AT)
Publication Details
- Journal
- Helvetica Chimica Acta
- Published
- 2024-12-25
- DOI
- https://doi.org/10.1002/hlca.202400167
- Primary Topic
- Advanced Chemical Physics Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Gordon and Betty Moore Foundation
- Universität Basel
- European Commission