Circulating miRNAs – a Potential Non-invasive Biomarker for Diagnosis of Endometriosis
Endometriosis is a debilitating disease affecting one in ten women worldwide. Due to several reasons the diagnosis is delayed for 7–11 years. Currently, the ultimate diagnostic procedure is laparoscopy followed by histological examination. The need for non-invasive biomarker is placed as a top priority according to the World Endometriosis Society. The present study includes 45 females – 30 patients with endometriosis at different stages and 15 healthy controls. An expression analysis of 84 circulating miRNAs was performed comparing between different groups of participants. Ten miRNAs with the most significant expression difference between females at early stage of endometriosis, advanced stage of endometriosis and healthy controls were nominated as a potential diagnostic and prognostic biomarker using a panel of miRNAs.
Authors
- Milen Dimitrov (ORCID: https://orcid.org/0000-0002-7744-0384)
- Liliya Koleva (ORCID: https://orcid.org/0000-0002-6081-8360)
- M Sokolov (ORCID: https://orcid.org/0000-0002-2608-333X)
- A. Kolev (ORCID: https://orcid.org/0009-0006-7992-0054)
- Silvia Nikolova
- Valentina Boyanova Petkova (ORCID: https://orcid.org/0000-0002-6938-1054)
- Diana Hristova (ORCID: https://orcid.org/0000-0002-9710-1312)
- Savina Petrova Hadjidekova (ORCID: https://orcid.org/0000-0002-4510-8512)
- Victoria Spasova (ORCID: https://orcid.org/0000-0003-4464-5436)
- Zora Hammoudeh
- Olga Antonova (ORCID: https://orcid.org/0000-0003-3123-4830)
- S Hitrova
- Ventsislava Pencheva (ORCID: https://orcid.org/0000-0001-7486-4774)
- Draga Toncheva (ORCID: https://orcid.org/0000-0002-2027-6122)
- Vesela Karamisheva (ORCID: https://orcid.org/0000-0003-0073-3303)
- Dejan Korunoski
Institutions
- Bulgarian Academy of Sciences (BG)
- Alexandrovska Hospital (BG)
- Tokuda Hospital (BG)
- Medical University of Sofia (BG)
- National Institute of Emergency Medicine "Pirogov" (BG)
- Acibadem City Clinic (BG)
- Maichin Dom (BG)
- National Center of Infectious and Parasitic Diseases (BG)
Publication Details
- Journal
- Proceedings of the Bulgarian Academy of Sciences
- Published
- 2024-12-25
- DOI
- https://doi.org/10.7546/crabs.2024.12.09
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00