OTULIN confers cisplatin resistance in osteosarcoma by mediating GPX4 protein homeostasis to evade the mitochondrial apoptotic pathway
This study highlights the importance of OTULIN in OS chemoresistance and provides a promising approach for targeting the OTULIN-GPX4 axis to improve the prognosis of OS patients. Our findings offer new insights into the molecular mechanisms underlying OS chemoresistance and suggest potential therapeutic targets for future clinical interventions.
Authors
- Fengjing Guo (ORCID: https://orcid.org/0000-0002-5968-4836)
- Yunhao Zeng (ORCID: https://orcid.org/0000-0002-5326-3977)
- Zhengqiang Luo
- Fei Xu (ORCID: https://orcid.org/0000-0001-8543-6636)
- Zehang Zheng
- Xing Bao
- Chuang Huang (ORCID: https://orcid.org/0000-0003-0030-5392)
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1186/s13046-024-03249-8
- Citations
- 10
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.34
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hubei Province