The effects of the antiviral agent T-1105 on various serotypes of foot-and-mouth disease virus

Foot-and-mouth disease (FMD) is a highly contagious viral disease that affects cloven-hoofed animals and is caused by the foot-and-mouth disease virus (FMDV), and results in significant economic losses in the livestock industry.The high genetic variability of FMDV poses a substantial challenge to vaccine efficacy.This study evaluates the antiviral efficacy of T-1105, an RNA-dependent RNA polymerase inhibitor, against FMDV.The cytotoxic concentration 50 (CC 50 ) and inhibitory concentration 50 (IC 50 ) of T-1105 were determined, and the sensitivity index (SI) was calculated.Results demonstrated that the SI value of T-1105 was lower than that of ribavirin, a standard antiviral agent.T-1105 exhibited partial antiviral activity against several FMDV subtypes, including O1/Manisa/Turkey/69, O/SKR/2000, A22/Iraq 24/64, A/Malaysia/97, Asia1/Shamir/89, and Asia1/MOG/05, with similar findings observed in RT-PCR assays except for Andong/SKR/2010 and O/SKR/2002.Overall, the antiviral effect of T-1105 exhibited narrow specificity against several serotypes of FMDV.