Gastric leiomyosarcoma in a Himalayan cat

A 2-year-old intact male Himalayan cat was presented with two months history of anorexia, vomiting and loss of body weight.Abdominal ultrasonography revealed abnormal mass in stomach.Surgical removal of gastric pyloric mass 331.5 cm in size at greater curvature was performed and then was submitted for diagnosis.Histopathologically, large neoplastic foci were occupied from submucosa to serosa in the stomach, and were consisted of interlacing fascicles of spindle cells with marked cellular pleomorphism including anisokaryosis, anisocytosis, and bi-nucleation.Tumor cells showed high mitotic figures and strong invasion to adjacent pancreas in tissue section were also observed.According to immunohistochemistry, the tumor cells demonstrated strong positive signals for vimentin and smooth muscle actin whereas no immunoreactivities were obtained for neuron specific enolase, and CD117.Based on the gross, histopathologic and immunohistochemical features, this case was diagnosed as feline gastric leiomyosarcoma.