Automated Blood Cell Detection and Classification in Microscopic Images Using YOLOv11 and Optimized Weights

<b>Background/Objectives:</b> Accurate detection and classification of blood cell types in microscopic images are crucial for diagnosing various hematological conditions. This study aims to develop and evaluate advanced architectures for automating blood cell detection and classification using the newly proposed YOLOv10 and YOLOv11 models, with a specific focus on identifying red blood cells (RBCs), white blood cells (WBCs), and platelets in microscopic images as a preliminary step of the complete blood count (CBC). <b>Methods</b>: The Blood Cell Count Detection (BCCD) dataset was enriched using data augmentation techniques to improve model robustness and diversity. Extensive experiments were performed, including complete weight initialization, advanced optimization strategies, and meticulous hyperparameter tuning for the YOLOv11 architecture. <b>Results</b>: The YOLOv11-l model achieved an overall mean Average Precision (mAP) of 93.8%, reflecting its robust accuracy across multiple blood cell types. <b>Conclusions</b>: The findings underscore the efficacy of the YOLOv11 architecture in automating blood cell classification with high precision, demonstrating its potential to enhance hematological analyses and support clinical diagnosis.