E46K α-Synuclein Mutation Fails to Promote Neurite Outgrowth by Not Inducing Cdc42EP2 Expression, Unlike Wild-Type or A53T α-Synuclein in SK-N-SH Cells
Our findings suggest that WT and mutant α-syn are linked to Cdc42EP2 production in neuritogenesis, implying α-syn involvement in the physiological function of axon growth and synapse formation. Thus, α-syn may be a potential therapeutic target for PD.
Authors
- Seonghan Kim (ORCID: https://orcid.org/0000-0002-6608-8215)
- Hye Sook Jung (ORCID: https://orcid.org/0000-0001-7940-7249)
Institutions
- Inje University (KR)
Publication Details
- Journal
- Brain Sciences
- Published
- 2024-12-25
- DOI
- https://doi.org/10.3390/brainsci15010009
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Inje University