Oxometallate-Based Ionic Liquid Catalyzed CO2-Promoted Hydration of Propargylic Alcohols for α-Hydroxy Ketones Synthesis
α-Hydroxy ketones are a crucial class of organic compounds prevalent in natural products and pharmaceutical molecules. The CO<sub>2</sub>-promoted hydration of propargylic alcohols is an efficient method for the synthesis of α-hydroxy ketones. Herein, an ionic liquid (IL) was designed to catalyze this reaction individually under atmospheric CO<sub>2</sub> pressure, volatile organic solvents, and additives. This IL, constructed from the molybdate anion, can be recycled from industrial (NH<sub>4</sub>)<sub>2</sub>MoO<sub>4</sub> production wastewater, demonstrating its high tolerance to catalytic environments and significant potential for practical applications. To our knowledge, this is the first instance of an oxometallate-based IL catalyst being utilized for the CO<sub>2</sub>-promoted hydration of propargylic alcohols. Further mechanistic studies revealed the bifunctionality of this IL in activating both CO<sub>2</sub> and substrates.
Authors
- Baisong Li
- Cheng Chen (ORCID: https://orcid.org/0000-0001-5439-5421)
- Francis Verpoort (ORCID: https://orcid.org/0000-0002-5184-5500)
- Ye Yuan
- Weidong Lin
- C.-J. Wang
- Yuankun Wang
- Qin Wang (ORCID: https://orcid.org/0009-0004-6997-0678)
Institutions
- Wuhan University of Technology (CN)
Publication Details
- Journal
- International Journal of Molecular Sciences
- Published
- 2024-12-25
- DOI
- https://doi.org/10.3390/ijms26010062
- Citations
- 1
- Primary Topic
- Carbon dioxide utilization in catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.18
Funders
- National Natural Science Foundation of China