Urolithin A Modulates PER2 Degradation via SIRT1 and Enhances the Amplitude of Circadian Clocks in Human Senescent Cells
The findings suggest that urolithins, particularly UA, have the potential to modulate the aging clock and may serve as therapeutic nutraceuticals for age-related disorders associated with circadian dysfunction.
Authors
- Norifumi Tateishi
- Yasukazu Nakahata (ORCID: https://orcid.org/0000-0003-3814-5822)
- Rassul Kuatov
- Jiro Takano
- Takayuki Izumo
- Hideyuki Arie (ORCID: https://orcid.org/0000-0001-9166-9831)
- Yoshihiro Nakao (ORCID: https://orcid.org/0000-0001-7597-6962)
- Masaru Kominami
- Wataru Nakamura (ORCID: https://orcid.org/0000-0001-5038-6114)
- Daisuke Takemoto (ORCID: https://orcid.org/0000-0003-3465-0581)
- Kazuyuki Shinohara (ORCID: https://orcid.org/0000-0001-6055-0547)
- Ken-ichi Wakabayashi
Institutions
- Suntory Foundation for Life Sciences (JP)
- Nagasaki University (JP)
Publication Details
- Journal
- Nutrients
- Published
- 2024-12-25
- DOI
- https://doi.org/10.3390/nu17010020
- Citations
- 5
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 1.37
Funders
- Japan Society for the Promotion of Science