Comparative Impact of Alternate-Day Fasting and Time-Restricted Feeding on Placental Function and Fetal Development in Maternal Obesity
Both ADF and TRF during pregnancy significantly mitigated metabolic impairments in obese dams on an HFD. TRF mice demonstrated enhanced placental nutrient transport and fetal development, associated with reduced endoplasmic reticulum (ER) stress and inflammatory responses. In contrast, ADF markedly intensified placental stress and inflammatory responses, diminished placental nutrient transport efficiency, and consequently induced fetal growth restriction.
Authors
- Ruihao Zhang (ORCID: https://orcid.org/0000-0002-3562-2382)
- Bin Feng (ORCID: https://orcid.org/0000-0001-6258-2729)
- Shihao Zhou
- Xi Ming Mo
- Lianqiang Che (ORCID: https://orcid.org/0000-0002-0940-7275)
- De Wu (ORCID: https://orcid.org/0000-0003-1873-9914)
- Chao Jin
- Yong Zhuo (ORCID: https://orcid.org/0000-0002-8348-4199)
- Siyuan Liu (ORCID: https://orcid.org/0000-0002-7274-9155)
- Shengyu Xu (ORCID: https://orcid.org/0000-0002-4415-8542)
- Xuemei Jiang (ORCID: https://orcid.org/0000-0003-1977-8536)
- Yan Lin (ORCID: https://orcid.org/0009-0002-0063-6685)
- Zhengfeng Fang (ORCID: https://orcid.org/0000-0002-6246-392X)
- Bing Lei
- Lun Hua (ORCID: https://orcid.org/0009-0000-6816-5192)
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Sichuan Agricultural University (CN)
Publication Details
- Journal
- Nutrients
- Published
- 2024-12-25
- DOI
- https://doi.org/10.3390/nu17010025
- Citations
- 4
- Primary Topic
- Dietary Effects on Health
- Type
- article
- Field-Weighted Citation Impact
- 1.31
Funders
- Natural Science Foundation of Sichuan Province