Enhanced itaconic acid secretion from macrophages mediates the protection of mesenchymal stem cell-derived exosomes on lipopolysaccharide-induced acute lung injury mice
ITA secretion facilitated the MSC-exos' protective benefits on LPS-induced PMVEC damage and ALI in mice by promoting AM M2 polarization, highlighting a potential therapeutic strategy for ALI and related inflammatory lung diseases.
Authors
- Zongan Liang (ORCID: https://orcid.org/0000-0002-8358-9177)
- Yanmei Wen
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
- Chengdu Second People's Hospital (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2024-12-26
- DOI
- https://doi.org/10.1186/s13062-024-00586-8
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.70