Agonists of the opioid δ‐receptor improve irritable bowel syndrome‐like symptoms via the central nervous system
We propose that agonists of opioid δ-receptors are potential drugs for the radical treatment of IBS because they can ameliorate IBS-like symptoms via the CNS, specifically the insular cortex.
Authors
- Mayuna Yamazaki
- Takumi Hamano
- Sayaka Kimiki
- Akiyoshi Saitoh (ORCID: https://orcid.org/0000-0001-8617-2441)
- Kazumi Yoshizawa (ORCID: https://orcid.org/0000-0001-7341-3381)
- Mengdie Ou
- Satoka Kasai (ORCID: https://orcid.org/0009-0000-3153-6869)
- Daisuke Yamada (ORCID: https://orcid.org/0000-0002-6989-6736)
- Tsuyoshi Saitoh (ORCID: https://orcid.org/0000-0001-6105-6292)
- Hiroshi Nagase
- Toshinori Yoshioka
- Keita Kajino
- Yumi Ode
- Rui Ehara
Institutions
- Tokyo University of Information Sciences (JP)
- University of Tsukuba (JP)
- Chiba University (JP)
- Tokyo University of Science (JP)
- Tsukuba International University (JP)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-12-25
- DOI
- https://doi.org/10.1111/bph.17428
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Core Research for Evolutional Science and Technology