Kidney Gastrin/CCKBR Attenuates Type 2 Diabetes Mellitus by Inhibiting SGLT2-Mediated Glucose Reabsorption through Erk/NF-κB Signaling Pathway
Our study underscores the crucial role of renal gastrin/CCKBR in SGLT2 regulation and glucose reabsorption, and renal gastrin/CCKBR can be a promising therapeutic target for diabetes.
Authors
- Xianxian Wu (ORCID: https://orcid.org/0009-0009-9475-7138)
- Meng Niu (ORCID: https://orcid.org/0009-0001-5374-4148)
- Xing Liu (ORCID: https://orcid.org/0000-0003-3655-5000)
- Xue Liu (ORCID: https://orcid.org/0000-0003-4779-8948)
- Dongfeng Shi
- Zhiwei Yang (ORCID: https://orcid.org/0000-0001-6943-004X)
- Yuhan Zhang (ORCID: https://orcid.org/0000-0002-6174-0462)
- Xue Zhang (ORCID: https://orcid.org/0000-0002-6436-3930)
- Yang Shi
Institutions
- Academy of Medical Sciences (GB)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Fuyang City People's Hospital (CN)
- Institute of Laboratory Animal Science (CN)
Publication Details
- Journal
- Diabetes & Metabolism Journal
- Published
- 2024-12-25
- DOI
- https://doi.org/10.4093/dmj.2023.0397
- Citations
- 3
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.07
Funders
- Chinese Academy of Medical Sciences
- National Key Research and Development Program of China