Ulcerative Colitis with Acute Pericarditis after Dose Escalation of Mesalazine
Mesalazine-induced pericarditis is rare, and most cases occur at the time of treatment initiation. A 30-year-old man with ulcerative colitis who had experienced remission for 2 years with mesalazine 2,000 mg/day subsequently experienced relapse. Therefore, the mesalazine dose was increased to 4,000 mg. Thereafter, hematochezia improved, but anterior chest pain developed. Chest radiography revealed marked cardiac dilation (cardiothoracic ratio, 63%) and echocardiography revealed pericardial effusion. Adverse events associated with mesalazine should be carefully monitored, not only at the time of treatment initiation but also after dose escalation.
Authors
- Jun Wada (ORCID: https://orcid.org/0000-0003-1468-5170)
- Naohiko Gunji (ORCID: https://orcid.org/0000-0003-0939-9444)
- Mai Murakami (ORCID: https://orcid.org/0000-0002-9454-3385)
- Hiromasa Ohira (ORCID: https://orcid.org/0000-0003-4331-0634)
- Michio Onizawa (ORCID: https://orcid.org/0000-0002-5685-5230)
- Shunsuke Miura (ORCID: https://orcid.org/0000-0001-7259-2242)
- Tomoaki Mochimaru (ORCID: https://orcid.org/0000-0002-7932-6569)
- Kazumasa Kawashima (ORCID: https://orcid.org/0000-0002-6320-2625)
- Yu Watahiki (ORCID: https://orcid.org/0000-0002-7896-8981)
- Chiharu Sakuma
Institutions
- Fukushima Medical University (JP)
Publication Details
- Journal
- Internal Medicine
- Published
- 2024-12-25
- DOI
- https://doi.org/10.2169/internalmedicine.4655-24
- Citations
- 2
- Primary Topic
- Pericarditis and Cardiac Tamponade
- Type
- article
- Field-Weighted Citation Impact
- 0.80