Structures of Polyacetoxybriaranes Extracted from the Sea Whip Octocoral <i>Junceella fragilis</i>
In the present study, an algae-containing octocoral, Junceella fragilis, was subjected to chemical screening. The analysis resulted in the extraction of six polyacetoxybriaranes: a new compound, identified as fragilide Z (1), alongside previously identified analogs, which included 12-epi-fragilide G (2), fragilide P (3), junceellolide D (4), junceellonoid A (5), and juncin ZI (6). The structures of compounds 2-6 were investigated through single-crystal X-ray diffraction analysis, whereas that of 1 was examined through two-dimensional nuclear magnetic resonance analysis. Compounds 1-6 proved active in enhancing the growth of MG-63 human mesenchymal stem cells.
Authors
- Yu‐Chia Chang (ORCID: https://orcid.org/0000-0002-7849-8254)
- Su‐Ying Chien (ORCID: https://orcid.org/0009-0008-0931-3149)
- Ping‐Jyun Sung (ORCID: https://orcid.org/0000-0001-8686-9193)
- Hai Nhat
- Yifeng Zeng (ORCID: https://orcid.org/0000-0003-2615-5994)
- Jui‐Hsin Su
- You-Ying Chen
- Chun‐Hsiung Huang
- Zhi-Hong Wen
- Li-Guo Zheng
Institutions
- Fu Jen Catholic University (TW)
- Chang Gung University of Science and Technology (TW)
- National Sun Yat-sen University (TW)
- Kaohsiung Medical University (TW)
- National Taiwan University (TW)
- Kaohsiung Armed Forces General Hospital (TW)
- National Museum of Marine Biology and Aquarium (TW)
- Pharmaceutical Biotechnology (Czechia) (CZ)
- China Medical University (CN)
Publication Details
- Journal
- Chemical and Pharmaceutical Bulletin
- Published
- 2024-12-25
- DOI
- https://doi.org/10.1248/cpb.c24-00574
- Citations
- 2
- Primary Topic
- Polyoxometalates: Synthesis and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.23
Funders
- National Sun Yat-sen University
- Sun Yat-sen University
- National Taiwan University
- Kaohsiung Armed Forces General Hospital
- National Science and Technology Council