THE EFFECTIVENESS OF THE USE OF A-PRF AND ENAMEL MATRIX PROTEINS IN THE STABILIZATION OF REGIONAL HEMODYNAMICS IN PATIENTS WITH GENERALIZED PERIODONTITIS II, II-III DEGREE

The severity of changes in local hemodynamics makes it possible to assess the severity of the pathological process and the effectiveness of the treatment of the disease. The aim of the study was to analyze the effectiveness of complex treatment of patients with generalized periodontitis II, II-III stage of development by using the enamel matrix protein drug "Emdogain" and the APRF technique. Materials and methods. 65 people aged 34-59 years with a diagnosis of generalized periodontitis (GP) II, II-III degrees took part in the study. Depending on the method of treatment, patients were divided into four groups. Rheographic studies were carried out using the rheographic computer complex "RHEOTEST" DXSystems and the program "Ascold / DX-Complex Regina 2000" / InitRegina. exe. Results and Discussion. Disorders of local hemodynamics and violations of the rheological properties of blood were observed in all patients with generalized periodontitis II, II-III degree. The analysis of qualitative indicators indicated a deviation from the normal configuration of the rheogram with a steep anakrota, a sharp peak and a smooth, sloping descending part. The values of the quantitative parameters of the patients' rheogram before treatment also differed significantly from the normal parameters. The lowest efficiency of treatment was observed in patients of the 1st group. 6 months after surgery, the RI value increased by 1.6 times, and the EBFI increased by 1.2 times. The average value of VTI decreased by 4.35%, PRI by 10.14%, VOI – by 5.04%. 12 months after the operation, deterioration of quantitative and qualitative indicators was observed. There was a positive trend compared to the data before surgery, but the results of the treatment were significantly different from the norm. In patients of the II group, after 6 months, a significant increase in RI and EBFI was observed by 2.1 and 1.5 times, respectively. Average values of VTI (by 7.43%), PRI (by 6.22%) and VOI (by 4.64%) decreased. After 12 months, a slight deterioration of rheographic indicators was observed compared to the results 6 months after the operation. In group III, after 3 and 6 months, similar dynamics were observed as in group II. The most pronounced changes were observed in patients of IV group. 6 months after treatment, the average values of RI and EBFI increased by 2.3 and 1.6 times, respectively. VTI, PRI and VOI decreased by 8.74%, 11.39% and 7.44%. After 12 months, the quantitative indicators were not significantly different compared to the indicators after 6 months.