THE ANTIMICROBIAL ACTION OF THE BIOLOGICALLY ACTIVE SUBSTANCE BASED ON AMINO ACID, OBTAINED BY THE SEMI-SYNTHETIC METHOD

The modern era, when antimicrobial resistance has become a global problem, is accompanied by increasing of the infections, caused by resistant microorganisms. The obtaining of new anti-microbial agents is one of the main direction against antimicrobial resistance. Although hundreds of antimicrobial agents have been discovered, only a small number of them are used in medi-cine. It is important to obtain antimicrobial agents based on substances with a new mechanism of action and without the toxic effect. In this regard, a new amino acid based biologically active substance - N-acylamino acid is ob-tained semi-synthetically, was studied. The antimicrobial activity, including the minimum inhibi-tory concentration (MIC) of this substance against the strains of Escherichia coli ATCC®25922™, Staphylococcus aureus ATCC®29213™, Klebsiella pneumoniae ATCC®700603™, Pseudomonas aeruginosa and Candida albicans was evaluated. It was found that the N-acylamino acid exerts an antimicrobial effect on bacteria at low con-centrations. Its MIC for E.coli and K.pneumoniae is 12.5 μg/ml, and for S.aureus and P.aeruginosa is 6.25 μg/ml. This substance does not exhibit antimicrobial activity against C.albicans. Possible mechanisms of the antimicrobial action of the N-acylamino acid are dis-cussed.