Relationship Between Placenta Previa and Premature Preterm Rupture of Membranes: Case-Cohort Study

Objective: This study aimed to evaluate whether the prevalence of premature preterm rupture of membranes (PPROM) is higher among patients with placenta previa. Material And Method: A retrospective screening was conducted on a total of 59,567 pregnant women who delivered at our hospital between 2016 and 2021. Among the patients, 1,721 pregnant women meeting the inclusion criteria with PPROM were identified. The participants were divided into two groups: PPROM without placenta previa (control group, n=1,698) and PPROM with placenta previa (n=23). The data were analyzed subsequently. Results: The birth week of PPROMs with placenta previa was found to be earlier (p = 0.028). The time between diagnosis and birth was shorter in PPROMs with placenta previa than in the second group (p < 0.001), and there was a higher frequency of clinical chorioamnionitis in these patients (p=0.037). The prevalence of PPROM with placenta previa was 8.4%, compared to 2.88% for PPROM without placenta previa, demonstrating a statistically significant difference (p < 0.001). Conclusion: Our study found a significantly higher prevalence of PPROM in patients with placenta previa compared to those without placenta previa. Moreover, the interval from diagnosis to delivery was shorter, and clinical chorioamnionitis was more common in patients with PPROM and placenta previa.