The same but different: impact of animal facility sanitary status on a transgenic mouse model of Alzheimer’s disease
Housing conditions affect the composition of the gut microbiota. Gut microbiota of 6-month-old conventionally bred Alzheimer's mice is dysbiotic. Gut dysbiosis is absent in Alzheimer's mice housed in highly sanitized facilities. Transfer of fecal microbiota from conventionally bred mice affects cognition. Microbiota of mice housed in highly sanitized facilities has no effect on cognition.
Authors
- Caroline Ismeurt (ORCID: https://orcid.org/0009-0005-9839-3571)
- Santiago Rivera (ORCID: https://orcid.org/0000-0001-6649-2712)
- Patrizia Giannoni (ORCID: https://orcid.org/0000-0003-2536-7688)
- Kévin Baranger (ORCID: https://orcid.org/0000-0001-8206-8874)
- Philippe Marin (ORCID: https://orcid.org/0000-0002-5977-7274)
- Benjamin Lelouvier (ORCID: https://orcid.org/0000-0002-8710-6777)
- Florence Servant (ORCID: https://orcid.org/0000-0003-1063-6531)
- Sylvie Claeysen (ORCID: https://orcid.org/0000-0002-0576-5518)
- Linda-Nora Mekki
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Montpellier (FR)
- Institut de Neurophysiopathologie (FR)
Publication Details
- Journal
- mBio
- Published
- 2025-04-17
- DOI
- https://doi.org/10.1128/mbio.04001-24
- Citations
- 4
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Association France Alzheimer
- Région Occitanie Pyrénées-Méditerranée
- European Regional Development Fund