A Pooled Pharmacokinetic Analysis for Piperacillin/Tazobactam Across Different Patient Populations: From Premature Infants to the Elderly
We developed a combined population PK model for PIP/TAZ across a broad range of patients covering the extremes of patient characteristics. This model can be used as a robust a priori model for Bayesian forecasting to achieve individualised dosing. The simulations indicate that adjustments based on the allometric theory as well as maturation and decline of CL of PIP may help the current dosing recommendations to provide consistent target attainment across patient populations.
Authors
- Jan J. De Waele (ORCID: https://orcid.org/0000-0003-1017-9748)
- Céline Thibault (ORCID: https://orcid.org/0000-0001-7612-2934)
- Douglas J. Eleveld (ORCID: https://orcid.org/0000-0002-0340-3847)
- Michael Zöller (ORCID: https://orcid.org/0000-0002-5337-6509)
- Johannes Zander (ORCID: https://orcid.org/0000-0003-4539-0703)
- Sutep Jaruratanasirikul (ORCID: https://orcid.org/0000-0002-8411-1407)
- Andrew Alexander Udy (ORCID: https://orcid.org/0000-0002-6284-2022)
- Pieter Colin (ORCID: https://orcid.org/0000-0003-3616-5539)
- Jeroen V. Koomen (ORCID: https://orcid.org/0000-0001-7253-3998)
- Jason A. Roberts (ORCID: https://orcid.org/0000-0001-6218-435X)
- Evelyn Dhont (ORCID: https://orcid.org/0000-0002-8969-2941)
- Robin Michelet (ORCID: https://orcid.org/0000-0002-5485-607X)
- Michel Struys (ORCID: https://orcid.org/0000-0003-0421-536X)
- Fekade B. Sime (ORCID: https://orcid.org/0000-0003-4061-2063)
- Pieter De Cock (ORCID: https://orcid.org/0000-0001-7634-7471)
- Caroline Damen
- Danny Tsai (ORCID: https://orcid.org/0000-0002-7059-8808)
- Daming Kong
- Sofie Dhaese (ORCID: https://orcid.org/0000-0002-2252-7167)
- Charlotte Kloft (ORCID: https://orcid.org/0000-0001-9344-8514)
- Michael Cohen-Wolkowiez
- Fabio Silvio Taccone
- Abdulrazzaq Alobaid
- Timothy Felton
- Jeffrey Lipman
Institutions
- Prince of Songkla University (TH)
- Université Libre de Bruxelles (BE)
- University Medical Center Groningen (NL)
- The University of Queensland (AU)
- University of Groningen (NL)
- Duke University (US)
- Université de Montpellier (FR)
- Royal Brisbane and Women's Hospital (AU)
- Ghent University Hospital (BE)
- The Alfred Hospital (AU)
- Centre Hospitalier Universitaire Sainte-Justine (CA)
- University of Manchester (GB)
- Ghent University (BE)
- Manchester University NHS Foundation Trust (GB)
- Saint John's Hospital (BE)
- Centre for Human Drug Research (NL)
- Alice Springs Hospital (AU)
- Université de Nîmes (FR)
- Freie Universität Berlin (DE)
Publication Details
- Journal
- Clinical Pharmacokinetics
- Published
- 2024-12-25
- DOI
- https://doi.org/10.1007/s40262-024-01460-6
- Citations
- 6
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 2.69
Funders
- China Scholarship Council