Endemic Period COVID-19 Risk Evolution Between 2023 and 2024 Years in a General Medicine Office in Toledo, Spain. Incidence Rate and Other Risk Measures are Declining or Stable

Background : The evolution of community risk measures for covid-19 infection from 2023 to 2024 is not clearly known. Objective: To know the evolution of risk measures of cases of covid-19 from October 1, 2022 to October 1, 2024 in a general medicine consultation in Toledo, Spain. Methodology: Comparison of the covid-19 Incidence Rate, Relative Risk and Attributable Risk in 2023 year versus covid-19 in 2024 (group with very broad hybrid immunity), based on data from previous longitudinal studies, all of them carried out in the same population of patients treated in a general medicine office in Toledo, Spain. Results: 76 covid-19 cases from October 2022 to October 2023 (1 year at risk) and 54 covid-19 cases from October 2023 to October 2024 (1 year at risk) were included, for a population at risk of 2,000 people. The raw Incidence Rate in 2024 vs. 2023 was lower (3% vs. 4%), Relative Risks were protective or equal and Attributable Risks were negative or equal for all variables studied (relative risk of moderate severe severity and the presence of chronic diseases had not changed). The following statistical significances were found in 2024 vs. 2023: lower Relative Risks for the entire population [RR= 0.75 (X2= 3.8481. p= .049801)], for women [0.6 (X2= 4.319. p= .037689)], and for socio-health workers [0.46 (X2= 4.2686. p= .038823)]. Conclusion: In general practice setting in Toledo, Spain, in 2024 vs. 2023 the incidence of covid-19 and other risk measures are decreasing or it are stable. Population at risk with greater hybrid immunity is better prepared than 2023 to avoid cases of covid-19, but the relative risk of moderate severe severity (which was already low) and the presence of chronic diseases (which was already high) have not changed.