Theranostic Rhenium(I)-Based ER-Phagy Retardant Promotes Immunogenic Cell Death
ER-phagy is a double-edged sword in the occurrence, development, and treatment of cancer; especially, its functions in immunotherapy are still unknown. In this work, we designed a theranostic Re complex (<b>Re1</b>) containing a BODIPY-derived ligand and a β-carboline ligand to target the endoplasmic reticulum (ER) and block ER-phagy at the late stages. Interestingly, as validated both in vitro and in vivo, ER-phagy blockage greatly enhances the capability of <b>Re1</b> to induce immunogenic cell death (ICD). In summary, we dexterously fused two molecular modules for ER targeting and ER-phagy blockage into a coordination complex to afford a highly effective ICD inducer, which provides clues for designing new cancer immunotherapeutics.
Authors
- Yu‐Yi Ling
- Cai‐Ping Tan (ORCID: https://orcid.org/0000-0003-3583-8367)
- Qing‐Hua Shen (ORCID: https://orcid.org/0000-0001-8359-9626)
- Hao Liang (ORCID: https://orcid.org/0000-0002-0284-1888)
- Jie Wang (ORCID: https://orcid.org/0000-0002-9819-5445)
- Zhiyuan Li (ORCID: https://orcid.org/0009-0003-1199-5234)
Institutions
- Sun Yat-sen University (CN)
- Guangdong Medical College (CN)
- State Key Laboratory of Synthetic Chemistry (CN)
- Marine Biomedical Research Institute of Qingdao (CN)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2024-12-25
- DOI
- https://doi.org/10.1021/acs.jmedchem.4c01948
- Citations
- 3
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.72
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities
- Basic and Applied Basic Research Foundation of Guangdong Province